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Infective dermatitis of Jamaican children 1966-1991 - abstract
West Indian med. j ; 41(1): 33, Apr. 1992.
Artigo em Inglês | MedCarib | ID: med-6455
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Infective dermatitis of Jamaican children, first described by Sweet in 1966, is a chronic eczema associated with persistent infection of the skin or anterior nares with either staphylococcus aureus or B haemolytic streptococcus, or both. In 1990, we reported a pilot study of 14 children with infective dermatitis (ID) and 11 with atopic eczema (AE) as controls, which showed that all the ID patients were positive for antibodies to the human T-lymhotrophic virus (HTLV-1). We postulated then that there was an association between HTLV-1 infection and infective dermatitis, and suggested that this organism might be causing ID through an immune mechanism. This paper reports on findings of a case control study of 50 ID patients and 36 AE patients undertaken between December, 1990 and August, 1991, which confirms the association between HTLV-I and infective dermatitis. All 50 patients with ID were positive for HTLV-I and antibodies, while the AC controls were all negative. In addition, when compared to the atopic controls, the ID patients had lower haemoglobins, higher white cell counts, and higher ESRs. They also had lower serum albumins and serum irons. Investigations of their immune systems showed that both groups had normal responses to delayed hypersensitivity skin tests, and normal complement levels. However, there was a marked increase in the activity of both T and B-lymphocyte systems, with all immunoglobulin levels being significantly increased in ID patients. The CD4 CD 8 ratio was increased, with an increase in the CD4 counts. Monoclonal antibody tests showed increased T-cell activation. The results confirm the association between HTLV-1 infection and infective dermatitis and confirm immune dysfunction. The precise mechanism of the immunodysregulation, however, remains to be determined (AU)
Assuntos
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Dermatite Tipo de estudo: Estudo observacional / Fatores de risco Limite: Criança / Humanos País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1992 Tipo de documento: Artigo / Congresso e conferência
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Dermatite Tipo de estudo: Estudo observacional / Fatores de risco Limite: Criança / Humanos País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1992 Tipo de documento: Artigo / Congresso e conferência
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