Myasthenia gravis and HLA phenotypes in Jamaicans
South Med J
; 85(9): 904-6, Sept. 1992.
Artigo
em Inglês
| MedCarib
| ID: med-7254
Biblioteca responsável:
JM3.1
Localização: JM3.1; R11.S68
ABSTRACT
We determined HLA-antigen frequencies and corresponding relative risks (RR) in 30 Jamaicans with myasthenia gravis (MG) and 40 normal controls.. using a microcytotoxicity assay and commercially prepared typing trays, we found that the strongest HLA associations with MG in Jamaicans were with HLA-A2 (RR = 6.15), HLA-B8 (RR = 3.4), HLA-B13 (RR=7.6), and DQw4 (RR = 3.8). After correction of the P value for the number of antigens tested, only HLA-A2 was stastistically significantly increased in MG patients. There was a statistically significant negative association between Mg and HLA-DR2, as well as as HLA-A9 and -B5. No correlation was observed between HLA phenotype, thymic disease, clinical grades, or disease course. HLA-A2 and sex were independent risk factors for MG, female patients having a higher risk (RR = 5.8). Further studies using larger patient and control groups, locally derived typing sera, and DNA probe analysis are indicated. (AU)
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Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Frequência do Gene
/
Antígenos HLA
/
Miastenia Gravis
Tipo de estudo:
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
South Med J
Ano de publicação:
1992
Tipo de documento:
Artigo