Osteoclasts in bone resorption: an experimental model

ABSTRACT

Osteoclasts are frequently, perhaps invariably, associated with resorbing surfaces of bone. Studies have been carried out in animals stained intra-vitally with alizarin red, supravitally with neutral red, and in controls, to determine criteria for resorption and the frequency of association of osteoclasts with this process. In these experiments, a constant association was found between the presence of osteoclasts may be utilised as "target areas" in order to test factors affecting osteoclast function (AU)