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Neonatal Screening for Haemoglobinopathies in South East London: findings and comparisons with Jamaica
Dick, M. C; Rochester Peart, C; Wild, B; Streetly, Alison; Serjeant, Graham R; Smith, G; Lorek, A; Layton, M; Bellingham, A. J.
Afiliação
  • Dick, M. C; Child Health Directorate, Lambeth Healthcare NHS Trust
  • Rochester Peart, C; Child Health Directorate, Lambeth Healthcare NHS Trust
  • Wild, B; Department of Haematological Medicine, KCSMD
  • Streetly, Alison; Department of Public Health Medicine, UMDS
  • Serjeant, Graham R; University of the West Indies, Mona, Jamaica. MRC Laboratory
  • Smith, G; Department of Haematology, Guy's and St. Thomas's NHS Trust
  • Lorek, A; Department of Paediatrics, Lewisham Hospital
  • Layton, M; Department of Haematological Medicine, KCSMD
  • Bellingham, A. J; Department of Haematological Medicine, KCSMD
In. United Medical and Dental Schools of Guy's & St. Thomas' Hospitals; King's College School of Medicine & Dentistry of King's College, London; University of the West Indies. Center for Caribbean Medicine. Research day and poster display. s.l, s.n, Jun. 30, 1997. p.1.
Não convencional em Inglês | MedCarib | ID: med-790
Biblioteca responsável: JM3.1
Localização: JM3.1; R855.5.C72C46 1997
ABSTRACT

INTRODUCTION:

Neonatal screening for sickle cell disorders has been shown to reduce mortality and morbidity. Methods of screening vary but in 1994, the local Health Authority funded universal neonatal screening across the whole of Lambeth, Southwark and Lewisham. This paper will report the findings of the first three years of operation of the programme and compare findings with the screening programme currently operating in Jamaica.

METHOD:

since May 1994 dried bloo[d] spots of all infants have been screened at King's College Hospital and screen positive cases followed up by counsellors. Infants are followed up at four sites (Guy's, King's, Lewisham and St.Thomas') according to parental preference. Minimum standards for follow-ups have been agreed by clinicians across all four sites and information of the success in achieving these standards is now being collected.

RESULTS:

Overall there have been 122 affected infants detected in the first two years 10 months of the programmes operation. This is made up of 83 HbSS, 35 HbSC, 4HbSBThal. This gives a birth preference of 23.4 per 1000 total population (2.3HbSS, 1.0 HbSC). Allowing for a termination rate of 20 percent this indicates that the expected birth prevalence in the district would be 4.2 per 1000 births. This compares with birth prevalence of of 0.3 per 1000 for congenital hypothyroidism, 06. per 1000 for cystic fibrosis and 0.1 for phenylketonuria. The distribution of the births is unevem with 57 in Southwark, 40 in Lambeth and 25 in Lewisham. The paper will report on the follow-up and outcome of care provided for this population to date.

Discussion:

South East London has the highest prevalence of sickle cell disorders of any district in the UK. Sickle cell disorder is now as common in South East London as it is in Jamaica. The follow-up arrangements established in South East London provide an opportunity for colloboration with the West Indies which may help to determine some of the reasons for differences in the natural course of the disease in these populations. The population based approach established should allow monitoring of the impact of community education and antenatal screening programmes on the birth prevalence over time. (AU)
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar / ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis / ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos Problema de saúde: Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos / Doenças de Células Falciformes / Cuidados de Saúde Neonatal / Doenças Não Transmissíveis Base de dados: MedCarib Assunto principal: Triagem Neonatal / Hemoglobinopatias / Anemia Neonatal / Anemia Falciforme Tipo de estudo: Estudo diagnóstico / Guia de prática clínica / Fatores de risco / Estudo de rastreamento Limite: Lactente / Recém-Nascido País/Região como assunto: Caribe Inglês / Europa / Jamaica Idioma: Inglês Ano de publicação: 1997 Tipo de documento: Não convencional
Buscar no Google
Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar / ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis / ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos Problema de saúde: Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos / Doenças de Células Falciformes / Cuidados de Saúde Neonatal / Doenças Não Transmissíveis Base de dados: MedCarib Assunto principal: Triagem Neonatal / Hemoglobinopatias / Anemia Neonatal / Anemia Falciforme Tipo de estudo: Estudo diagnóstico / Guia de prática clínica / Fatores de risco / Estudo de rastreamento Limite: Lactente / Recém-Nascido País/Região como assunto: Caribe Inglês / Europa / Jamaica Idioma: Inglês Ano de publicação: 1997 Tipo de documento: Não convencional
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