Atopic dermatitis and HTLV-1 associated-myelopathy: associated or coincidental disorders?
Dermatology
; 199(4): 356-60, 1999.
Artigo
em Inglês
| MedCarib
| ID: med-859
Biblioteca responsável:
JM3.1
Localização: JM3.1;
ABSTRACT
Reports from Jamaica have indicated that some patients with infective dermatitis or atopic dermatitis (AD) are seropositive for antibodies to human T-lymphotropic virus type 1 (HTLV-1). We describe a 32-year-old Israeli woman with long-term AD and paresthesia in the distal parts of the extremities. Neurological examination revealed a positive Babinski's sign. HLA typing demonstrated that this patient has the common HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis haplotype for DRBI* DQBI*. The presence of HTLV-1 was demonstrated with polymerase chain reaction; HTLV-1-antibodies were detected by the Western blot method and by inoculation of the patient's peripheral blood mononuclear cells into F344 rats. This study confirms the presence of HTLV-1 antibodies and proviral genome in a patient with AD which later evolved into HAM/TSP. We cannot yet conclude whether these two diseases are associated or coincidental disorders.(Au)
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Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Doenças da Medula Espinal
/
Vírus Linfotrópico T Tipo 1 Humano
/
Infecções por HTLV-I
/
Dermatite Atópica
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Dermatology
Ano de publicação:
1999
Tipo de documento:
Artigo