Genetic variation at the immunoglobulin allotype loci in Creoles of Trinidad
Am J Phys Anthropol
; 81(4): 555-62, Apr. 1990.
Artigo
em Inglês
| MedCarib
| ID: med-8760
Biblioteca responsável:
JM3.1
ABSTRACT
The sera of a sample of 204 Creoles from Trinidad were tested for the presence of polmorphic gene complexes occurring on immunoglobulin light and heavy-chain molecules including the allotypic markers IGKC 1, IGHA2 1 and 2, IGHG1 A, X, F, and Z, and IGHG3 G, G5, B0, B1, B3, B4, B5, C3, C5, S, and T. Nine IGHG (GM) haplotypes occur in polymorphic frequencies (greater than .01) in this population, including known African, Asian, Caucasian, and Amerindian marker haplotypes. Significant differences (P less than .01) were found in the frequency distributions of three IGHI (GM) haplotypes and the frequency of IGKC*1 in these data and data from Creole populations of Belize and St. Vincent. The Creoles of Trinidad and St. Vincent are more similar in IGHG (GM) haplotype distributions than are Trinidad and Belize populations. Previous testing has revealed no significant differences between St. Vincent and Belize Creoles at the Ig allotypic loci. Analysis of migration patterns in the Caribbean suggests that different rates of Asian migration have maintained regional diversity at these loci, while continuous gene flow from the eastern Caribbean to Trinidad has had a relative homogenising effect on the gene pools of this area. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Variação Genética
/
Alótipos de Imunoglobulina
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Am J Phys Anthropol
Ano de publicação:
1990
Tipo de documento:
Artigo