Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome
J Clin Pathol
; 44(3): 194-9, Mar 1991.
Artigo
em Inglês
| MedCarib
| ID: med-9460
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB1.J62
ABSTRACT
Caecal biopsy specimens from Jamaican children with the Trichuris dysentery syndrome (TDS) and age matched Jamaican controls were investigated by immunohistochemistry and by light microscopy. Biopsy specimens from all children (with TDS and controls) showed a mild to moderate increase in inflamatory cells. Except in the vicinity of the worm, where the epithlium was flattened, there was no other epithelial abnormality. Compared with controls, children with TDS had increased IgM lamina propria plasma cells and decreased intaepithelial T cells. There was also an increase in crypt epithelial cells proliferation. Lamina propia T cells (both activated and non-activated) were no more common in children with the Trichuris syndrome than controls. Epithelial cell HLA-DR and VLA-1 expression (which are increased in other colitides) were the same in both groups. Despite the presence of large worm burdens and chronic dysentery, therefore, only minor changes were seen in the caecal mucosa of children with TDS. (AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Diarreia
/
Helmintíase
/
Doenças Negligenciadas
Base de dados:
MedCarib
Assunto principal:
Tricuríase
/
Ceco
/
Disenteria
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J Clin Pathol
Ano de publicação:
1991
Tipo de documento:
Artigo