Antimicrobial resistance in Helicobacter pylori in Barbados
West Indian med. j
; 49(Supp 2): 36, Apr. 2000.
Artigo
em Inglês
| MedCarib
| ID: med-955
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
OBJECTIVE:
Helicobacter pylori eradication is essential in patients with peptic ulcer who are infected with the organism. The rate of eradication is related to the level of antimicrobial resistance to metronidazole, clarithromycin, amoxycillin and tetracycline in H pylori in this community. DESIGN ANDMETHODS:
Gastric biopsies from all patients undergoing upper gastrointestinal endoscopy were cultured. Isolation was done on Thayer-Martin medium under microaerophilic conditions and isolates were sub-cultured on chocolate agar. MICs were determined using the E-test.RESULTS:
64 isolates were available for testing. Metronidazole resistance (MIC > 8mg/l) was observed in 39 percent (25/64), clarithromycin resistance (MIC > 2mg/l) in 4.7 percent (3/64), amoxycillin resistance (MIC > 8mg/l) in 4.7 percent (3/64) and tetracycline resistance (MIC > 4mg/l) in 3.1 percent (2/64).CONCLUSIONS:
The high level of metronidazole resistance precludes the use of this antibiotic as first line therapy for H pylori in Barbados. It is recommended that a proton pump inhibitor, amoxycillin and clarithromycin be the combination of choice for eradication of H pylori in patients in Barbados.(Au)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Úlcera Péptica
/
Resistência Microbiana a Medicamentos
/
Helicobacter pylori
Limite:
Humanos
País/Região como assunto:
Barbados
/
Caribe Inglês
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
2000
Tipo de documento:
Artigo