Is there an acute-phase response in steady-state sickle cell disease?
Lancet
; 341(8846): 651-3, Mar. 13 1993.
Artigo
em Inglês
| MedCarib
| ID: med-9591
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.L3
ABSTRACT
Metabolic and serum changes during steady-state homozygous sicle cell (SS) disease are consistent with an acute-phase response and raise the possibility that inflammation occurs in SS disease even during the steady state. To test this hypothesis, we measured concentrations of acute phase reactants in patients with SS disease, in patients with sickle cell haemoglobin C (SC) disease, and in normal (AA) control subjects. The concentrations of C-reactive protein and serum amyloid A were increased above 10 mg/L and 5mg/L, respectively (our definition of an acute-phase response) in 18 percent (26/143) of subjects with SS disease even when they were symptom free, in 17 percent (6/35) of subjects with SC disease, and in 1 percent (1/80) of AA controls (p<0.001). We suggest that subclinical vaso-occlusion may generate a covert inflammatory response and that the cytokine mediators of this response may contribute to the metabolic abnormalities and growth failure in sickle cell disease.(AU)
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Base de dados:
MedCarib
Assunto principal:
Viscosidade Sanguínea
/
Proteínas de Fase Aguda
/
Doença da Hemoglobina SC
/
Anemia Falciforme
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Lancet
Ano de publicação:
1993
Tipo de documento:
Artigo