Multiple scherosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom
J Neurol Neurosurg Psychiatry
; 54(8): 689-94, Aug. 1991.
Artigo
em Inglês
| MedCarib
| ID: med-9704
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC321.J62
ABSTRACT
Forty four consecutive patients of Afro-Caribbean origin resident in the United Kingdom (UK) were studied, based on a provisional diagnosis of myelopathy of unknown cause, tropical spastic paraparesis (TSP) or multiple scherosis (MS). Of 30 patients with progressive paraparesis 27 had serum antibodies to HTLV-1 and were classified as having TSP. Fourteen patients fulfilled the criteria for MS and none of 12 tested had HTLV-1 antibodies. All the TSP patients and nine of those with MS were born in West Indies. Five of the West Indian born MS patients had migrated to the UK after adolescence but the duration of residents in the UK before symptoms of MS developed was similar to those born in the UK (average 18 years). The features that differentiated MS from TSP patients, apart from HTLV-1 status, included clinical evidence of cranial nerve involvement, more extensive abnormalities on the brain and cervical cord MRI and asymmetry of the VEP latency increase, all of which were more frequent in the MS group. Of the three patients without a diagnosis one, born in the UK, had marked abnormalities on MRI of the brain indistinguishable from those seen in MS (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Infecções por HTLV-I
/
Paraparesia Espástica Tropical
/
Comparação Transcultural
/
Esclerose Múltipla
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe
/
Europa
Idioma:
Inglês
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
1991
Tipo de documento:
Artigo