Interferencia entre as vacinas anti-sarampo e antipoliomielite / Interference between measles and polio vaccines

ABSTRACT

The purpose of this study was to determine whether Sabin oral polio vaccine (OPV-Sabin) interferes with the serologic efficacy of measles vaccine administered subsequently. To this end, a study was made of 117 infants nine months old to whom attenuated live measles virus vaccine (BIKEN CAM 70 strain) was administered within a period of four weeks or less after receiving oral polio vaccine (OPV-Sabin), and of a control group of 88 infants of the same age to whom OPV-Sabin had not been recently administered.IgC antibodies to measles were studied by indirect inmunofluorescence. The proportion of seroconversion for measles vaccine was 19/23 (82.6 per cent) in the infants who had received OPV-Sabin two to six days before, 29/37(78.4 per cent) in those who had received OPV-Sabin nine to thirteen days before, 32/42 (76.2 per cent) in those in which OPV-sabin had been given 16 to 20 days before, and 12/15 (80.0 per cent) in the infants who had received the two vaccinations 23 to 26 days apart. The proportion of seroconversion in the control group (the infants vaccinated for weeks or longer after having received OPV-Sabin) was 68/88 (77.8 per cent). A comparison of these ratios brought out no statistically significant differences. Hence, the results obtained do no show reduced serologic efficacy of measles vaccine in infants