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Maternal cytokine response after SARS-CoV-2 infection during pregnancy
Frederieke A.J. Gigase; Nina M. Molenaar; Roy D. Missall; Anna-Sophie Rommel; Whitney Lieb; Erona Ibroci; Sophie Ohrn; Jezelle Lynch; Florian Krammer; Rachel Brody; Rebecca H. Jessel; Rhoda S. Sperling; Corina Lesseur; Francesco Callipari; Romeo R. Galang; Margaret C. Snead; Teresa Janevic; Joanne Stone; Elizabeth A. Howell; Jia Chen; Victor J.M. Pop; Siobhan M. Dolan; Veerle Bergink; Lotje D. De Witte.
Afiliação
  • Frederieke A.J. Gigase; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Nina M. Molenaar; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Roy D. Missall; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Anna-Sophie Rommel; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Whitney Lieb; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Erona Ibroci; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Sophie Ohrn; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Jezelle Lynch; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Florian Krammer; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Rachel Brody; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Rebecca H. Jessel; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Rhoda S. Sperling; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Corina Lesseur; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Francesco Callipari; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Romeo R. Galang; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA
  • Margaret C. Snead; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA
  • Teresa Janevic; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Joanne Stone; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Elizabeth A. Howell; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Jia Chen; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Victor J.M. Pop; Department of Clinical and Medical Psychology, Tilburg University, Tilburg, The Netherlands
  • Siobhan M. Dolan; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Veerle Bergink; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  • Lotje D. De Witte; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-474908
ABSTRACT
ObjectiveDysregulation of the immune system during pregnancy is associated with adverse pregnancy outcomes. Recent studies report cytokine changes during the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We examine whether there is a lasting association between SARS-CoV-2 infection during pregnancy and peripheral blood cytokine levels. Study designWe conducted a case-control study at the Mount Sinai health system in NYC including 100 SARS-CoV-2 IgG antibody positive people matched to 100 SARS-CoV-2 IgG antibody negative people on age, race/ethnicity, parity, and insurance status. Blood samples were collected at a median gestational age of 34 weeks. Levels of 14 cytokines were measured. ResultsIndividual cytokine levels and cytokine cluster Eigenvalues did not differ significantly between groups, indicating no persisting maternal cytokine changes after SARS-CoV-2 infection during pregnancy. ConclusionOur findings suggest that the acute inflammatory response after SARS-CoV-2 infection may be restored to normal values during pregnancy.
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Experimental_studies / Estudo observacional / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Experimental_studies / Estudo observacional / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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