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Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals
Alena Janda Markmann; Natasa Gaillourou; D. Ryan Bhowmik; Yixuan J. Hou; Aaron Lermer; David R. Martinez; Lakshmanane Premkumar; Heather Root; David van Duin; Sonia Napravnik; Stephen D. Graham; Quique Guerra; Rajendra Raut; Christos J. Petropoulos; Terri Wrin; Caleb Cornaby; John Schmitz; JoAnn Kuruc; Susan Weiss; Yara Park; Ralph Baric; Aravinda M. de Silva; David M. Margolis; Luther A. Bartelt.
Afiliação
  • Alena Janda Markmann; University of North Carolina Chapel Hill
  • Natasa Gaillourou; University of Cyprus
  • D. Ryan Bhowmik; University of North Carolina at Chapel Hill
  • Yixuan J. Hou; University of North Carolina at Chapel Hill
  • Aaron Lermer; University of North Carolina at Chapel Hill
  • David R. Martinez; University of North Carolina at Chapel Hill
  • Lakshmanane Premkumar; University of North Carolina at Chapel Hill
  • Heather Root; University of North Carolina at Chapel Hill
  • David van Duin; University of North Carolina at Chapel Hill
  • Sonia Napravnik; University of North Carolina at Chapel Hill
  • Stephen D. Graham; University of North Carolina at Chapel Hill
  • Quique Guerra; University of North Carolina at Chapel Hill
  • Rajendra Raut; University of North Carolina at Chapel Hill
  • Christos J. Petropoulos; Monogram Biosciences
  • Terri Wrin; Monogram Biosciences
  • Caleb Cornaby; University of North Carolina at Chapel Hill
  • John Schmitz; University of North Carolina at Chapel Hill
  • JoAnn Kuruc; University of North Carolina at Chapel Hill
  • Susan Weiss; University of North Carolina at Chapel Hill
  • Yara Park; University of North Carolina at Chapel Hill
  • Ralph Baric; University of North Carolina at Chapel Hill
  • Aravinda M. de Silva; University of North Carolina at Chapel Hill
  • David M. Margolis; University of North Carolina at Chapel Hill
  • Luther A. Bartelt; University of North Carolina at Chapel Hill
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21250493
Artigo de periódico
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ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2. Using convalescent sera collected from 101 COVID-19 recovered individuals 21-212 days after symptom onset with forty-eight additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations between individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to six months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex. We also show that SARS-CoV-2 convalescent neutralizing antibodies are higher in individuals with cardio-metabolic comorbidities. SignificanceIn this study we found that neutralizing antibody responses in COVID-19 convalescent individuals vary in magnitude but are durable and correlate well with RBD Ig binding antibody levels compared to other SARS-CoV-2 antigen responses. In our cohort, higher neutralizing antibody titers are independently and significantly associated with male sex compared to female sex. We also show for the first time, that higher convalescent antibody titers in male donors are associated with increased age and symptom grade. Furthermore, cardio-metabolic co-morbidities are associated with higher antibody titers independently of sex. Here, we present an in-depth evaluation of serologic, demographic, and clinical correlates of functional antibody responses and durability to SARS-CoV-2.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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