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Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in an longitudinally sampled cohort of COVID-19 outpatients
Annukka A. R. Antar; Tong Yu; Nora Pisnic; Razvan Azamfirei; Jeffrey A Tornheim; Diane M. Brown; Kate Kruczynski; Justin P. Hardick; Thelio Sewell; Minyoung Jang; Taylor Church; Samantha N. Walch; Carolyn Reuland; Vismaya S. Bachu; Kirsten Littlefield; Han-Sol Park; Rebecca L. Ursin; Abhinaya Ganesan; Oyinkansola Kusemiju; Brittany Barnaba; Curtisha Charles; Michelle Prizzi; Jaylynn R. Johnstone; Christine Payton; Weiwei Dai; Joelle Fuchs; Guido Massaccesi; Derek T. Armstrong; Jennifer L. Townsend; Sara C. Keller; Zoe O Demko; Chen Hu; Mei-Cheng Wang; Lauren M. Sauer; Heba H. Mostafa; Jeanne C. Keruly; Shruti H. Mehta; Sabra L. Klein; Andrea L. Cox; Andrew Pekosz; Christopher D. Heaney; David L. Thomas; Paul W. Blair; Yukari C. Manabe.
Afiliação
  • Annukka A. R. Antar; The Johns Hopkins University School of Medicine
  • Tong Yu; The Johns Hopkins University School of Medicine
  • Nora Pisnic; The Johns Hopkins University Bloomberg School of Medicine
  • Razvan Azamfirei; The Johns Hopkins University School of Medicine
  • Jeffrey A Tornheim; The Johns Hopkins University School of Medicine
  • Diane M. Brown; The Johns Hopkins University School of Medicine
  • Kate Kruczynski; The Johns Hopkins University Bloomberg School of Public Health
  • Justin P. Hardick; The Johns Hopkins University School of Medicine
  • Thelio Sewell; The Johns Hopkins University School of Medicine
  • Minyoung Jang; The Johns Hopkins University School of Medicine
  • Taylor Church; The Johns Hopkins University School of Medicine
  • Samantha N. Walch; The Johns Hopkins University School of Medicine
  • Carolyn Reuland; The Johns Hopkins University School of Medicine
  • Vismaya S. Bachu; The Johns Hopkins University School of Medicine
  • Kirsten Littlefield; The Johns Hopkins University Bloomberg School of Public Health
  • Han-Sol Park; The Johns Hopkins University Bloomberg School of Public Health
  • Rebecca L. Ursin; The Johns Hopkins University Bloomberg School of Public Health
  • Abhinaya Ganesan; The Johns Hopkins University Bloomberg School of Public Health
  • Oyinkansola Kusemiju; The Johns Hopkins University School of Medicine
  • Brittany Barnaba; The Johns Hopkins University School of Medicine
  • Curtisha Charles; The Johns Hopkins University School of Medicine
  • Michelle Prizzi; The Johns Hopkins University School of Medicine
  • Jaylynn R. Johnstone; The Johns Hopkins University School of Medicine
  • Christine Payton; The Johns Hopkins University School of Medicine
  • Weiwei Dai; The Johns Hopkins University School of Medicine
  • Joelle Fuchs; The Johns Hopkins University School of Medicine
  • Guido Massaccesi; The Johns Hopkins University School of Medicine
  • Derek T. Armstrong; The Johns Hopkins University School of Medicine
  • Jennifer L. Townsend; The Johns Hopkins University School of Medicine
  • Sara C. Keller; The Johns Hopkins University School of Medicine
  • Zoe O Demko; The Johns Hopkins University School of Medicine
  • Chen Hu; The Johns Hopkins University School of Medicine
  • Mei-Cheng Wang; The Johns Hopkins University Bloomberg School of Public Health
  • Lauren M. Sauer; The Johns Hopkins University School of Medicine
  • Heba H. Mostafa; The Johns Hopkins University School of Medicine
  • Jeanne C. Keruly; The Johns Hopkins University School of Medicine
  • Shruti H. Mehta; The Johns Hopkins University Bloomberg School of Public Health
  • Sabra L. Klein; The Johns Hopkins University Bloomberg School of Public Health
  • Andrea L. Cox; The Johns Hopkins University School of Medicine
  • Andrew Pekosz; The Johns Hopkins University Bloomberg School of Public Health
  • Christopher D. Heaney; The Johns Hopkins University Bloomberg School of Public Health
  • David L. Thomas; The Johns Hopkins University School of Medicine
  • Paul W. Blair; The Johns Hopkins University School of Medicine
  • Yukari C. Manabe; The Johns Hopkins University School of Medicine
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21252420
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ABSTRACT
BackgroundSustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) in mild to moderate COVID-19 is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. MethodsNinety-five outpatients self-collected mid-turbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples at home and in a research clinic a median of 6 times over 1-3 months. Samples were tested for viral RNA, virus culture, and SARS-CoV-2 and other human coronavirus antibodies, and associations were estimated using Cox proportional hazards models. ResultsViral RNA clearance, as measured by SARS-CoV-2 RT-PCR, in 507 URT samples occurred a median (IQR) 33.5 (17-63.5) days post-symptom onset. Sixteen nasal-OP samples collected 2-11 days post-symptom onset were virus culture positive out of 183 RT-PCR positive samples tested. All participants but one with positive virus culture were negative for concomitant oral fluid anti-SARS-CoV-2 antibodies. The mean time to first antibody detection in oral fluid was 8-13 days post-symptom onset. A longer time to first detection of oral fluid anti-SARS-CoV-2 S antibodies (aHR 0.96, 95% CI 0.92-0.99, p=0.020) and BMI [≥] 25kg/m2 (aHR 0.37, 95% CI 0.18-0.78, p=0.009) were independently associated with a longer time to SARS-CoV-2 viral RNA clearance. Fever as one of first three COVID-19 symptoms correlated with shorter time to viral RNA clearance (aHR 2.06, 95% CI 1.02-4.18, p=0.044). ConclusionsWe demonstrate that delayed rise of oral fluid SARS-CoV-2-specific antibodies, elevated BMI, and absence of early fever are independently associated with delayed URT viral RNA clearance.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint