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Antibody response to SARS-CoV-2 infection over six months among Nicaraguan outpatients
Filemon Bucardo; Fredman Gonzalez; Omar Zepeda; Christian T Toval Ruiz; Armando J Matute; Hernan Vanegas; Nancy Munguia; Edwing Centeno; Yaoska Reyes; Johan Nordgren; Lennart Svensson; Aravinda M de Silva; LAKSHMANANE PREMKUMAR; Silvia Becker-Dreps.
Afiliação
  • Filemon Bucardo; National Autonomous University of Leon, Nicaragua (UNAN-Leon).
  • Fredman Gonzalez; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Omar Zepeda; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Christian T Toval Ruiz; National Autonomous University of Leon, Nicaragua (Leon)
  • Armando J Matute; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Hernan Vanegas; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Nancy Munguia; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Edwing Centeno; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Yaoska Reyes; National Autonomous University of Leon, Nicaragua (UNAN-Leon)
  • Johan Nordgren; Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
  • Lennart Svensson; Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
  • Aravinda M de Silva; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA
  • LAKSHMANANE PREMKUMAR; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599
  • Silvia Becker-Dreps; Departments of Family Medicine and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21256122
ABSTRACT
New information is emerging about SARS-CoV-2 epidemiology and immunity, but little of this information comes from low- and middle-income countries or from patients receiving care in the outpatient setting. The current study investigated the SARS-CoV-2 infection status and antibody responses in 157 patients seeking care for a respiratory disease suggestive of COVID-19 in private healthcare clinics during the first wave (June-October 2020) of infections in Nicaragua. We examined nasal swabs for the presence of viral RNA via RT-PCR and longitudinally collected sera for the changes in SARS-CoV-2 Spike antibody levels over six months. Among patients with confirmed SARS-CoV-2 infections, we evaluated if clinical symptoms were associated with age, hematological parameters and co-morbidities. The combination of PCR and paired serology identified 60 (38%) of the 157 outpatients as acute COVID-19. While both PCR and serology identified the majority (n = 38, 64%) of the acute infections, a notable number of outpatients were identified by RT-qPCR (n = 13, 22%) or by serology (n = 9, 14%) only. During the longitudinal study, we identified 6 new infections by serology among the 97 non-COVID-19 subjects. In conclusion, this study report that more than one third of the outpatients seeking care for acute respiratory disease during the first epidemic wave of SARS-CoV-2 in Nicaragua had an acute mild COVID-19 infection that correlate with prolonged humoral response. This immune response to the RBD antigen, more likely IgG dependent, significantly increased between the acute to convalescent and decay in the late convalescent but still remained seropositive.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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