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Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection
Urs Heilbronner; Fabian Streit; Thomas Vogl; Fanny Senner; Schaupp Sabrina; Daniela Reich-Erkelenz; Sergi Papiol; Mojtaba Oraki Kohshour; Farahnaz Klohn-Saghatolislam; Janos L Kalman; Heilbronner Maria; Katrin Gade; Ashley L Comes; Monika Budde; Till FM Andlauer; Heike Anderson-Schmidt; Kristina Adorjan; Til Sturmer; Adrian Loerbroks; Manfred Amelang; Eric Poisel; Jerome Foo; Stefanie Heilmann-Heimbach; Andreas J Forstner; Franziska Degenhardt; Jorg Zimmermann; Jens Wiltfang; Martin von Hagen; Carsten Spitzer; Max Schmauss; Eva Reininghaus; Jens Reimer; Carsten Konrad; Georg Juckel; Fabian U Lang; Markus Jager; Christian Figge; Andreas J Fallgatter; Detlef E Dietrich; Udo Dannlowski; Bernhardt T Baune; Volker Arolt; Ion-George Anghelescu; Markus M Nothen; Stephanie H Witt; Ole A Andreassen; Chi-Hua Chen; Peter Falkai; Marcella Rietschel; Thomas G Schulze; Eva C Schulte.
Afiliação
  • Urs Heilbronner; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Fabian Streit; Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
  • Thomas Vogl; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Fanny Senner; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Schaupp Sabrina; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Daniela Reich-Erkelenz; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Sergi Papiol; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Mojtaba Oraki Kohshour; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Farahnaz Klohn-Saghatolislam; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Janos L Kalman; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Heilbronner Maria; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Katrin Gade; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Ashley L Comes; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Monika Budde; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Till FM Andlauer; Department of Neurology, Technical University Munich, Munich, Germany
  • Heike Anderson-Schmidt; Department of Psychiatry, University of Gottingen, Germany
  • Kristina Adorjan; Institute of Psychiatric Genomics and Phenomics, University of Munich
  • Til Sturmer; University of North Carolina
  • Adrian Loerbroks; University of Dusseldorf, Dusseldorf, Germany
  • Manfred Amelang; Department of Psychology, University of Heidelberg, Heidelberg, Germany
  • Eric Poisel; Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
  • Jerome Foo; Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
  • Stefanie Heilmann-Heimbach; Institut of Human Genetic, University of Bonn, Bonn, Germany
  • Andreas J Forstner; Institute for Human Genetics, University of Bonn, Bonn, Germany
  • Franziska Degenhardt; University of Essen, Essen, Germany
  • Jorg Zimmermann; Karl-Jaspers-Klinik, Bad Zwischenahn, Germany
  • Jens Wiltfang; Department of Psychiatry, University of Gottingen, Germany
  • Martin von Hagen; Clinical Center Werra-Meissner, Eschwege, Germany
  • Carsten Spitzer; University of Rostock, Rostock, Germany
  • Max Schmauss; Department of Psychiatrie, University of Augsburg, Augsburg, Germany
  • Eva Reininghaus; University of Graz, Graz, Austria
  • Jens Reimer; Department of Psychiatry, University of Hamburg, Hamburg, Germany
  • Carsten Konrad; Agaplesion Diakonieklinikum, Rotenburg, Germany
  • Georg Juckel; Department of Psychiatry, University of Bochum, Bochum, Germany
  • Fabian U Lang; Department of Psychiatry, Ulm University, Ulm, Germany
  • Markus Jager; Department of Psychiatry, Ulm University, Ulm, Germany
  • Christian Figge; European Medical School, Oldenburg, Germany
  • Andreas J Fallgatter; Department of Psychiatry, University of Tubingen, Tubingen, Germany
  • Detlef E Dietrich; AMEOS Clinical Center, Hildesheim, Germany
  • Udo Dannlowski; Department of Psychiatry, University of Munster, Munster, Germany
  • Bernhardt T Baune; Department of Psychiatry, University of Munster, Munster, Germany
  • Volker Arolt; Institute of Translational Psychiatry, University of Munster, Munster, Germany
  • Ion-George Anghelescu; Department of Psychiatry, Mental Health Institute of Berlin, Berlin, Germany
  • Markus M Nothen; Institute of Human Genetics, University of Bonn, Bonn, Germany
  • Stephanie H Witt; Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
  • Ole A Andreassen; NORMENT, University of Oslo, Oslo, Germany
  • Chi-Hua Chen; Department of Radiology, University of California San Diego, San Diego, USA
  • Peter Falkai; Department of Psychiatry, University of Munich, Munich, Germany
  • Marcella Rietschel; Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
  • Thomas G Schulze; Institute of Psychiatric Genomics and Phenomics, University of Munich, Munich, Germany
  • Eva C Schulte; University of Munich
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21263447
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ABSTRACT
BackgroundThe SARS-CoV-2 pandemic, with all its impacts on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behavior and, therefore, the risk of contracting the virus. AimsWe examined overlapping genetic underpinnings between major psychiatric disorders, personality traits, and susceptibility to SARS-CoV-2 infection. MethodsLinkage disequilibrium score regression was used to explore the genetic correlations of COVID-19 susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n=1346) and the HeiDE (n=3266) study), polygenic risk scores were used to analyze if a genetic association between, psychiatric disorders, personality traits, and COVID-19 susceptibility exists in individual-level data. ResultsWe observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (p=1.47x10-5; rg=0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies. ConclusionsWe identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Estudo observacional / Estudo prognóstico / Pesquisa qualitativa Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Estudo observacional / Estudo prognóstico / Pesquisa qualitativa Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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