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Increased Risk of Poor Clinical Outcome in COVID-19 Patients with Diabetes Mellitus and in-hospital Mortality Predictors: A Retrospective Cohort from a Tertiary Hospital in Indonesia
Md Ikhsan Mokoagow; Dante Saksono Harbuwono; Ida Ayu Kshanti; Cleopas Martin Rumende; Imam Subekti; Kuntjoro Harimurti; Khie Chen Lie; Hamzah Shatri.
Afiliação
  • Md Ikhsan Mokoagow; Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Fatmawati General Hospital
  • Dante Saksono Harbuwono; Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas In
  • Ida Ayu Kshanti; Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Fatmawati General Hospital
  • Cleopas Martin Rumende; Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia
  • Imam Subekti; Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas In
  • Kuntjoro Harimurti; Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia
  • Khie Chen Lie; Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia
  • Hamzah Shatri; Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21266217
ABSTRACT
AimTo determine association between diabetes in confirmed cases of COVID-19 and intensive care admission and in-hospital mortality, evaluate several laboratory parameters as mortality predictor, and develop predictors of in-hospital mortality among diabetics with COVID-19. MethodsThis retrospective cohort recruited all cases of COVID-19 hospitalized in Fatmawati General Hospital during March to October 2020. Inclusion criteria was RT-PCR confirmed cases of COVID-19 who aged 18 years and older while exclusion criteria were incomplete medical record or cannot be found and pregnant women. ResultsWe enrolled 506 participants to this study with median age of 51 years (IQR22), female (56.32%), and diabetes (28.46%). Diabetes increased intensive care admission (adjusted OR6.07;95%CI3.52-10,43) and in-hospital mortality (adjusted OR50;95%CI1.61-3.89). In predicting in-hospital mortality, ferritin and lactate dehydrogenase offered an acceptable discrimination, AUC0.71 (95%CI 0.62-0.79) and AUC0.70 (95%CI 0.61-0.78), respectively. The optimal cut-off of predicting mortality for ferritin was 786 g/mL and for LDH was 514.94 u/L. Factors include age above 70 years old, RBGs level on admission above 250 mg/dL or below 140 mg/dL, ferritin level above 786 ng/mL, and presence of ARDS increased the odds of mortality among individuals with diabetes. ConclusionsDiabetes increases risk of intensive care admission and in hospital mortality in COVID-19. Multivariate analysis showed that older age, RBG on admission, high ferritin level, presence of ARDS increased the odds of mortality among individuals with diabetes.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Experimental_studies / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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