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Screening for SARS-CoV-2 persistence in Long COVID patients using sniffer dogs and scents from axillary sweats samples
Dominique GRANDJEAN; Dorsaf SLAMA; Capucine GALLET; Clothilde JULIEN; Emilie SEYRAT; Marc BLONDOT; Maissa BENAZAZIEZ; Judith ELBAZ; Dominique SALMON.
Afiliação
  • Dominique GRANDJEAN; Ecole Nationale Veterinaire d'Alfort
  • Dorsaf SLAMA; Assistance Publique Hopitaux de Paris
  • Capucine GALLET; National Veterinary School of Alfort
  • Clothilde JULIEN; National Veterinary School of Alfort
  • Emilie SEYRAT; Long COVID patients, France
  • Marc BLONDOT; Long COVID patients, France
  • Maissa BENAZAZIEZ; Assistance Publique Hopitaux de Paris
  • Judith ELBAZ; Long COVID patient, France
  • Dominique SALMON; Assistance Publique Hopitaux de Paris
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21268036
ABSTRACT
ObjectivesDogs can be trained to identify several substances not detected by humans, corresponding to specific volatile organic compounds (VOCs). The presence of VOCs, triggered by SARS-CoV-2 infection, was tested in sweat from Long COVID patients. Patients and methodsAn axillary sweat sample of Long COVID patients and of COVID-19 negative, asymptomatic individuals was taken at home to avoid any hospital contact. Swabs were randomly placed in olfaction detection cones, and the material sniffed by at least 2 trained dogs. ResultsForty-five Long COVID patients, mean age 45 (6-71), 73.3% female, with prolonged symptoms evolving for a mean of 15.2 months (5-22) were tested. Dogs discriminated in a positive way 23/45 (51.1%). Long COVID patients versus 0/188 (0%) control individuals (p<.0001). ConclusionThis study suggests the persistence of a viral infection in some Long COVID patients and the possibility of providing a simple, highly sensitive, non-invasive test to detect viral presence, during acute and extended phases of COVID-19.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo diagnóstico / Experimental_studies / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo diagnóstico / Experimental_studies / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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