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SARS-CoV-2 screening in patients in need of urgent inpatient treatment in the Emergency Department (ED) by digitally integrated point-of-care PCR: A clinical cohort study
Martin Mockel; Myrto Bolanaki; Joerg Hofmann; Angela Stein; Jennifer Hitzek; Fabian Holert; Antje Fischer-Rosinsky; Anna Slagman.
Afiliação
  • Martin Mockel; Charite - Universitatsmedizin Berlin
  • Myrto Bolanaki; Charite - Universitatsmedizin Berlin
  • Joerg Hofmann; Labor Berlin GmbH
  • Angela Stein; Labor Berlin GmbH
  • Jennifer Hitzek; Charite - Universitatsmedizin Berlin
  • Fabian Holert; Charite - Universitatsmedizin Berlin
  • Antje Fischer-Rosinsky; Charite - Universitatsmedizin Berlin
  • Anna Slagman; Charite - Universitatsmedizin Berlin
Preprint em Inglês | medRxiv | ID: ppmedrxiv-22268603
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ABSTRACT
Patients in need of urgent inpatient treatment were recruited prospectively. A rapid point of care PCR test (POC-PCR; Liat(R)) for SARS-CoV2 was conducted in the ED and a second PCR-test from the same swab was ordered in the central laboratory (CL-PCR). POC-PCR analyzers were digitally integrated in the laboratory information system. Overall, 160 ED patients were included. A valid POC-PCR-test result was available in 96.3% (n=154) of patients. N=16 patients tested positive for SARS-CoV-2 (10.0%). The POC PCR test results were available within 102 minutes (median, IQR 56-211), which was significantly earlier compared to the CL PCR (811 minutes; IQR 533-1289, p < 0.001). The diagnostic accuracy of the POC-PCR test was 100%. The implementation and digital LIS integration was successfully done. Staff satisfaction with the POC process was high. The POC-PCR testing in the emergency department is feasible and shows a very high diagnostic performance. Trial registration DRKS00019207
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Cohort_studies / Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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