Influence of fenvalerate and quercetin on hepatic antioxidant enzymes.

ABSTRACT

Pyrethroids are a class of neurotoxic pesticides with high selectivity for insects. Fenvalerate is a synthetic pyrethroid pesticide used to protect a variety of crops. Fenvalerate has been reported to exert deleterious effects on non target organisms including mammals. Recently, Fenvalerate was reported to cause liver damage in rats probably by generating oxidative stress while Quercetin, a potential antioxidant, has been reported to posses hepatoprotective activity. Therefore, the aim of the present investigation was to assess the ability of Quercetin to protect liver from Fenvalerate induced toxicity. In the present investigation an effort was made to evaluate the effect of Quercetin and Fenvalerate on hepatic G 6PD, GST and GR. Fenvalerate administration demonstrated significant reduction in the activities of hepatic G-6-PD, GST and GR while rats co treated with Quercetin showed significant recovery in the activities of these antioxidant enzymes.