Anxiolytic and Antiulcer Activity of Leaves of Andrographys Paniculata in Experimental Model.

ABSTRACT

The Petroleum ether and Chloroform extract of Andrographis paniculata leaves was investigated for its potential to protect gastric mucosa against pylorus ligation induced ulcer and to find out the anxiolytic action in elevated plus maze model. Chloroform extract at the dose of 200mg/kg protected the gastric mucosa in the pylorus ligation ulcer induction significantly (p<0.001) when compared with that of the standard drug famotidine (10mg/kg) and acts as a potent antiulcer effect. Elevated plus maze results were significant in alleviating the anxiety in the animals’ results in increased time spent and entries into the open arm compared with the standard drug diazepam (1mg/kg).