Risk factors affecting the prognosis of sepsis patients with blood transfusion / 中国输血杂志

ABSTRACT

【Objective】 To explore the factors affecting the prognosis of sepsis patients with blood transfusion, and provide safe and scientific blood transfusion recommendations for them. 【Methods】 The clinical data of 134 sepsis patients in our hospital from January 2018 to June 2021 were collected through retrospective analysis, and divided into the blood transfusion group (n=45) and non-transfusion group (n=89) according to whether they received transfusion or not. The basic clinical data and laboratory indicators of two groups were compared. According to the survival outcome and the occurrence of septic shock, patients in the blood transfusion group were subdivided into death group (n=17) and survival group (n=28), shock group (n=12) and non-shock group (n=33). Logistic regression analysis was used to analyze the risk factors that affect the survival outcome of septic patients after blood transfusion and the occurrence of septic shock. 【Results】 Statistical differences were noticed inblood transfusion group and the non-transfusion group by Hb (71.4±15.7 vs 100.6±21.9) g/L, PCT (13.7±27.2 vs 6.7±18.1) ng/mL, CRP (80.4±81.9 vs 46.6±67.1) mg/mL, APTT (43.4±22.6 vs 33.3±12.8) s, Fib (3.0±1.7 vs 4.0±1.7) g/L, LAC (3.4±4.2 vs 1.9±2.7) mmol/L, length of hospital stay (20.6±18.7 vs 14.1±10.9)d, and survival outcomes (P<0.05). Multivariate logistic regression analysis showed that red blood cell storage days (OR=0.183) and patient Hb level (OR=0.034) were risk factors that affected the survival outcome of sepsis patients after blood transfusion (P<0.05). 【Conclusion】 Compared with the non-blood transfusion group, the patients in the blood transfusion group had longer hospital stays, and different survival outcomes. The red blood cell storage days and Hb level of patients were the risk factors affecting the survival outcome of sepsis patients after blood transfusion, and RBCs with shorter storage period were suggested for sepsis patients.