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The effect of gingkgo biloba extra on spatial learning-memory in rats with chronic hypoxic hypercapnia / 中国现代医生
China Modern Doctor ; (36): 1-3,10, 2015.
Article em Zh | WPRIM | ID: wpr-1037548
Biblioteca responsável: WPRO
ABSTRACT
Objective To observe changes of spatial learning-memory in rats with chronic hypoxic hypercapnia and the effect of gingkgo biloba extra. Methods After established the rat model of chronic hypoxic hypercapnia,seventy-two rats were randomly divided into four groups normal control (NC),hypoxic-hypercapnia 4-week (4HH),hypoxic-hy-percapnia 4-week+gingkgo biloba extra (EGb)high dose(100 mg/kg)group[4HH+EGb(H)] and hypoxic-hypercapnia 4-week+EGb low dose (50 mg/kg) group[4HH+EGb(L)]. Praxiology in rats was asessed by the Morris water maze and step down test. Results The spatial learning-memory in rats exposed to chronic hypoxic-hypercapnia 4-week(4HH group)were displayed significant impairment in their performance,the longer mean escape latencies and swim path dis tances,the more error times. 4HH+EGb(H) and 4HH+EGb(L)groups shortened the reaction time of leaning, pro longed the latent time of memory, reduced times of mistakes. Conclusions EGb can enhance the capacity of learning-memory in the rats exposed chronic hypoxic hypercapnia.
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Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: China Modern Doctor Ano de publicação: 2015 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: China Modern Doctor Ano de publicação: 2015 Tipo de documento: Article