A Case of Adrenocortical Carcinoma with Concurrent Cushing's Syndrome and Primary Aldosteronism / 대한내분비학회지
Journal of Korean Society of Endocrinology
; : 446-451, 2004.
Article
em Ko
| WPRIM
| ID: wpr-131897
Biblioteca responsável:
WPRO
ABSTRACT
An adrenocortical carcinoma is a rare malignancy, which is associated with a poor prognosis. Eighty percent of adrenal tumors are functional, and commonly secrete glucocorticoids alone (45%), glucocorticoids and androgens (45%) or androgen alone (10%). Less than 1% of all cases secrete aldosterone. A case of a 75 year old female patient was experienced, presenting with anadrenocortical carcinoma and associated concurrent Cushing's syndrome and primary aldosteronism. She had complained of left flank pain for 5 months, and also showed clinical features of Cushing's syndrome, hypertension, hypokalemia and a left abdominal mass. An abdominal CT* demonstrated a large left adrenal mass, with necrosis, and a hemorrhage in the left upper abdomen. The plasma renin activity was 0.51 ng/ml/hr, and the serum aldosterone level was increased by 46.4 ng/dL. A low and high dose dexamethasone suppression test revealed no suppression. Histologically, the tumor was diagnosed as a adrenocortical carcinoma. After complete removal of the mass, she received mitotan and prednisolone as adjuvant therapies. Liver and bone metastasis occurred after 6 months of treatment, so was treated with palliative radiotherapy for the bone metastasis
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Plasma
/
Prognóstico
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Radioterapia
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Dexametasona
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Prednisolona
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Renina
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Carcinoma Adrenocortical
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Síndrome de Cushing
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Dor no Flanco
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Aldosterona
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
Idioma:
Ko
Revista:
Journal of Korean Society of Endocrinology
Ano de publicação:
2004
Tipo de documento:
Article