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Bioidentical Hormone Therapy in Postmenopausal Women / 대한폐경학회지
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wpr-132424
Biblioteca responsável: WPRO
ABSTRACT
Bioidentical hormone therapy (BHT) refers to the use of hormones that are molecularly and chemically identical to endogenous hormones for purposes of hormone replacement therapy. The specific hormones used in BHT include estrone, estradiol, estriol, progesterone and testosterone. Since the result of the Women's Health Initiative (WHI) trial documented the increased risk of breast cancer, cardiovascular disease and stroke in users of conventional hormone therapy (CHT), use of CHT has declined and there has been increased interest in BHT. Bioidentical hormones have some distinctly different physiologic effects compared with synthetic hormones. Synthetic progestin is associated with an increased risk for breast cancer and cardiovascular disease, while natural progesterone is associated with a decreased risk of breast cancer and cardiovascular disease. Estriol has some unique physiologic effects, which differentiate it from estrone and estradiol. Estriol is associated with a lower risk of breast cancer and would be expected to prevent breast cancer, but few randomized controlled trials have been documented. Some clinical data demonstrate that BHT is associated with a lower risk of breast cancer and cardiovascular disease, and is more efficacious than synthetic hormones. However, there is little evidence in support of this claim. Moreover, estriol has not been approved by the U.S. Food and Drug Administration (FDA). Further studies are needed to confirm the safety and efficacy of BHT.
Assuntos

Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Progesterona / Testosterona / United States Food and Drug Administration / Neoplasias da Mama / Hidroxitolueno Butilado / Menopausa / Doenças Cardiovasculares / Saúde da Mulher / Terapia de Reposição Hormonal / Acidente Vascular Cerebral Tipo de estudo: Ensaio clínico controlado Limite: Feminino / Humanos Idioma: Coreano Revista: The Journal of Korean Society of Menopause Ano de publicação: 2010 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Progesterona / Testosterona / United States Food and Drug Administration / Neoplasias da Mama / Hidroxitolueno Butilado / Menopausa / Doenças Cardiovasculares / Saúde da Mulher / Terapia de Reposição Hormonal / Acidente Vascular Cerebral Tipo de estudo: Ensaio clínico controlado Limite: Feminino / Humanos Idioma: Coreano Revista: The Journal of Korean Society of Menopause Ano de publicação: 2010 Tipo de documento: Artigo
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