An overview of the pathogenic mechanisms of autoimmune thyroid disorders / 고신대학교의과대학학술지
Kosin Medical Journal
; : 93-98, 2014.
Article
em En
| WPRIM
| ID: wpr-149028
Biblioteca responsável:
WPRO
ABSTRACT
Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown. Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves' disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Tireoglobulina
/
Doenças da Glândula Tireoide
/
Glândula Tireoide
/
Tireoidite
/
Tireoidite Autoimune
/
Tireotropina
/
Autoimunidade
/
Doença de Graves
/
Prevalência
/
Fatores de Risco
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Kosin Medical Journal
Ano de publicação:
2014
Tipo de documento:
Article