Influence of Bile Duct Ligation on 54 Liver Regeneration in Rats
Journal of the Korean Surgical Society
; : 785-789, 1997.
Article
em Ko
| WPRIM
| ID: wpr-165568
Biblioteca responsável:
WPRO
ABSTRACT
N/AWe evaluate the regenerating capacity of rat liver according to the severity and duration of the obstructive jaundice. Also we evaluate the regenerating capacity of hepatectomized rat liver according to the duration of the obstructive jaundice. The 10 week-old Sprague-Dawley rats were used. Common bile duct ligation and sequential partial hepatectomies were done. The regenerating capacity was measured by tritiated thymidine incorporation into rat liver DNA. The rate of incorporation of thymidine into DNA in the jaundiced livers increased significantly compared with that in the sham-operated liver on day 3.In jaundiced rats, the regenerating capacity after partial epatectomy decreased markedly without a return toward normal on day 3 and kept low thereafter. The duration of obstructive jaundice may be a key factor in the regeneration of rat liver after partial hepatectomy.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Regeneração
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Timidina
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Bile
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Ductos Biliares
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DNA
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Ratos Sprague-Dawley
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Ducto Colédoco
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Icterícia Obstrutiva
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Hepatectomia
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Ligadura
Limite:
Animals
Idioma:
Ko
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
1997
Tipo de documento:
Article