Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
The Korean Journal of Internal Medicine
; : 84-90, 2012.
Article
em En
| WPRIM
| ID: wpr-181913
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we evaluated the effects of NDC-052 as an add-on therapy in patients with mild to moderate asthma using inhaled corticosteroids (ICS).METHODS:
In a non-comparative, multi-center trial, 148 patients taking ICS received NDC-052 for eight weeks. We evaluated their forced expiratory volume in one second (FEV1), morning and evening peak expiratory flow rate (AM and PM PEFR), AM/PM asthma symptom scores, visual analogue symptom (VAS) scores, night-time wakening, frequency of short-acting beta2-agonist usage, and adverse events.RESULTS:
After eight weeks, both AM and PM PEFRs were significantly improved. Asthma symptom scores, VAS scores, the frequency of nights without awakening, and the frequency of beta2-agonist use were also reduced. Most of the adverse drug reactions were mild and resolved spontaneously.CONCLUSIONS:
The addition of NDC-052 to ICS had a beneficial effect on asthma control in patients with mild to moderate asthma, with good tolerability and fewer side effects. Further studies are necessary to evaluate the effects of NDC-052 in patients with severe and/or refractory asthma.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Asma
/
Fatores de Tempo
/
Índice de Gravidade de Doença
/
Administração por Inalação
/
Medicamentos de Ervas Chinesas
/
Pico do Fluxo Expiratório
/
Volume Expiratório Forçado
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Corticosteroides
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2012
Tipo de documento:
Article