Recent progress on miRNAs in the pathogenesis of colon cancer / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 297-299, 2008.
Article
em Zh
| WPRIM
| ID: wpr-229769
Biblioteca responsável:
WPRO
ABSTRACT
microRNAs (miRNAs) are endogenous, small noncoding RNA molecules discovered in animals, plants and viruses. They play a critical role in developmental and physiological processes and are implicated in the pathogenesis of many human cancers. Presently, human cancer, including colorectal cancer, is recognized as both a genetic and epigenetic disease. Changes induced by miRNAs are considered as epigenetic changes. Experiments were largely performed to analyze the colorectal microRNAome and bio-networking involving miRNAs. This review focuses on recent advances in colorectal miRNA expression profiles. Further, we discuss the regulatory network of miRNAs in the initiation and carcinogenesis of colon cancer in order to open up an avenue of anticancer therapy based on the epigenetic regulation by miRNAs.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias do Colo
/
MicroRNAs
/
Epigênese Genética
/
Genética
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Article