Stereoselective pharmacokinetics of tetrahydropalmatine in rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 746-749, 2005.
Article
em Zh
| WPRIM
| ID: wpr-253576
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.</p><p><b>METHODS</b>The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.</p><p><b>RESULTS</b>The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.</p><p><b>CONCLUSION</b>Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Plantas Medicinais
/
Estereoisomerismo
/
Alcaloides de Berberina
/
Farmacocinética
/
Estrutura Molecular
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
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Área Sob a Curva
/
Corydalis
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article