Effects of matrine, oxymatrine and resveratrol on HERG channel expression / 药学学报
Acta Pharmaceutica Sinica
; (12): 139-144, 2007.
Article
em Zh
| WPRIM
| ID: wpr-281953
Biblioteca responsável:
WPRO
ABSTRACT
Because HERG potassium channel has important effects on both proarrhythmia and antiarrhythmia, we use immunofluorescence and Western blotting methods to detect the expression of HERG channel of HERG-HEK cells in different concentrations of matrine, oxymatrine and resveratrol. The findings showed that both matrine (1 micromol x L(-1) ) and oxymatrine ( 1micromol x L (-1) ) increased HERG channel expression ( n = 5, P < 0. 05 ) , while matrine (100 micromol x L(-1) ) decreased HERG channel expression ( n = 5, P < 0. 05), resveratrol didn't affect HERG channel expression. In conclusion, different concentrations of matrine and oxymatrine affect HERG channel expression, while there is no relationship between resveratrol and HERG channel expression. It provides a theoretical support for the safety and mechanism of anti-arrhythmic drugs.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Fisiologia
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Plantas Medicinais
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Quinolizinas
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Estilbenos
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Linhagem Celular
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Química
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Western Blotting
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Imunofluorescência
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Técnicas de Patch-Clamp
Limite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Article