Research progress on the relationship between SLCO1B1 gene and neonatal jaundice / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1183-1187, 2014.
Article
em Zh
| WPRIM
| ID: wpr-289506
Biblioteca responsável:
WPRO
ABSTRACT
Organic anion transporter 2 (OATP2) is an uptake transporter located on the basolateral membrane of human hepatocytes. It mediates the transportation of various organic solutes including bilirubin and impacts bilirubin metabolism. It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the gene variants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin elimination and result in neonatal hyperbilirubinemia. In recent years, some studies have indicated that variants of SLCO1B1 are associated with neonatal jaundice. This article reviews the research advance in SLCO1B1 with respect to the structure and function and the relationship between SLCO1B1 mutations and neonatal jaundice.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Transportadores de Ânions Orgânicos
/
Transportador 1 de Ânion Orgânico Específico do Fígado
/
Genética
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Deficiência de Glucosefosfato Desidrogenase
/
Icterícia Neonatal
Limite:
Humans
/
Newborn
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2014
Tipo de documento:
Article