Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 830-833, 2010.
Article
em Zh
| WPRIM
| ID: wpr-293471
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of stomatin-like protein-2 (SLP-2) in esophageal squamous cell carcinoma (ESCC), and analyze the correlation between SLP-2 expression and clinicopathological features.</p><p><b>METHODS</b>The expression of SLP-2 protein in ESCC tissues (18 and 220 cases respectively) was detected by Western blot and IHC. The association between SLP-2 expression and clinicopathological features was analyzed.</p><p><b>RESULTS</b>Compared with normal epithelium, 13 cases of ESCC tissues showed a higher expression of SLP-2 on the protein level (72.2%, 13/18). IHC analysis on tissue microarray revealed that the expression rate of SLP-2 protein in ESCC was 54.1% and in normal esophageal mucosa was 3.6%, showing a significant difference (P < 0.001). SLP-2 high-level expression correlates with the extent of ESCC invasion (P = 0.033), but not with other clinicopathologic characteristics (P > 0.05).</p><p><b>CONCLUSION</b>SLP-2 as a novel cancer-related gene may play an important role in tumorigenesis of ESCC. The overexpression of SLP-2 may be closely associated with the invasion of esophageal cancer.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Fisiologia
/
Neoplasias Esofágicas
/
Imuno-Histoquímica
/
Proteínas Sanguíneas
/
Carcinoma de Células Escamosas
/
Western Blotting
/
Metástase Linfática
/
Proteínas de Membrana
/
Metabolismo
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2010
Tipo de documento:
Article