Influences of orthodontic tooth movement on estrous cycle and estrogen in rats / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the influences of orthodontic tooth movement on estrous cycle and estrogen in female rats.</p><p><b>METHODS</b>Two hundred female rats were divided into control group, one-time activation group, four-time activation group and sham-operated group. Each group was divided again into 4 sub-groups according to the different stage of the estrous cycle. The force-loading groups received repeated intermittent force. Serum estrogen was measured and the change of estrous cycle was recorded.</p><p><b>RESULTS</b>There were significant variations in the estrogen level among the groups which received mechanical force during the same stage of the estrous cycle (P < 0.01) and among the subgroups within each group (P < 0.05). These experimental treatments affected the estrous cycle of the rats in the groups received force in metestrus and diestrus.</p><p><b>CONCLUSIONS</b>Estrus of rats was the appropriate time for the orthodontic force.</p>