Therapeutic effect of docetaxel combined with oxaliplatin for treatment of recurrent epithelial ovarian cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 2319-2320, 2009.
Article
em Zh
| WPRIM
| ID: wpr-325120
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of docetaxel (Taxotere) (DTX) and oxaliplatin (OXA) for treatment of recurrent epithelial ovarian cancer.</p><p><b>METHODS</b>Thirty-six patients with histologically confirmed recurrent epithelial ovarian cancer received chemotherapy with DTX and OXA. DTX at the dose of 75 mg/m(2) was administered on day 1 by intravenous infusion in 60 min, followed by OXA at 100 mg/m(2) given by a 2 h infusion. The chemotherapy cycles were repeated every 21 days, and the patients received at least 2 cycles.</p><p><b>RESULTS</b>All the patients were available for response evaluation, among whom 3 (8.3%) showed complete responses and 17 (47.2%) showed partial responses, with an overall response rate of 55.6%. The main adverse effects included hematological toxicities and peripheral neuropathy.</p><p><b>CONCLUSION</b>Combination of DTX and OXA produces good therapeutic effect with tolerable toxicity profile for treatment of recurrent epithelial ovarian cancer.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Compostos Organoplatínicos
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Neoplasias Ovarianas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Cistadenoma Seroso
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Cistadenoma Mucinoso
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Taxoides
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Usos Terapêuticos
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Tratamento Farmacológico
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Recidiva Local de Neoplasia
Limite:
Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Article