Effect of losartan on produce of sera autoantibodies to angiotensin II-1 receptor in renovascular hypertension rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 43-46, 2003.
Article
em Zh
| WPRIM
| ID: wpr-339684
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM AND METHODS</b>The effects of losartan (after operation 2 week to 10 week, 5 mg/kg d ig) on generation of AT1R-AA in sera were observed during development of hypertension in rats. The renovascular hypertension (RVH) model was established by two-kidney one-clip method, a synthetic peptide corresponding to amino acid sequence 165-191 of the second extracellular loop of the angiotensin II-1 receptor (AT1R) was used as antigen, SA-ELISA were used to examine sera AT1R autoantibody (AT1R-AA).</p><p><b>RESULTS</b>The frequencies and titres of AT1R-AA after operation one week rats were significantly increased (P < 0.05). The treatment with losartan not only inhibited structural and functional changes, but also the frequencies and titres of AT1R-AA was significantly lower (P < 0.05) than RVH group.</p><p><b>CONCLUSION</b>It is suggested that the losartan significantly inhibits generation of the AT1R-AA.</p>
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Autoanticorpos
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Sangue
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Receptores de Angiotensina
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Ratos Wistar
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Losartan
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Alergia e Imunologia
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Hipertensão Renovascular
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2003
Tipo de documento:
Article