Advances in the structure-activity relationship study of natural flavonoids and its derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 622-630, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348909
Biblioteca responsável:
WPRO
ABSTRACT
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Antivirais
/
Farmacologia
/
Plantas Medicinais
/
Relação Estrutura-Atividade
/
Vasodilatadores
/
Flavonoides
/
Química
/
Antissepsia
/
Fibrinolíticos
/
Anti-Inflamatórios
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article