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Mechanism of delaying aging process with optimal stress / 中华行为医学与脑科学杂志
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-402173
Biblioteca responsável: WPRO
ABSTRACT
Objective  To study the mechanism of delaying aging process under optimal stress . Methods  Kunming mice swam at the 18℃ water temperature for 15min everyday based upon the model of aging mice induced by D-galactose .After six weeks continuously , the ability of memory and learning , the contents of SOD and MDA were measured, at the same time ,the mitochondria membranous fluidity ,MDA's contents in mitochondria and the activity of ATPase in hippocampus were also determined.Results  In the aging mice, a significant reduction of learning and memory ability was observed, the contents of SOD decreased , but MDA contents increased markedly, we also found a obvious declining at the ATPase activity and the fluidity of mitochondria membrane . But the optimal swimming stress could effectually antagonize the above-mentioned changes . Conclusions  The optimal swimming stress could delay the aging process by regulating the balance between the oxidant system and the antioxidant system.
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Behavioral Medicine and Brain Science Ano de publicação: 2001 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Behavioral Medicine and Brain Science Ano de publicação: 2001 Tipo de documento: Artigo
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