Progress in the relationship between environmental estrogen bisphenol A and obesity / 国际儿科学杂志

ABSTRACT

Bispheno|A(BPA)is an endocrine disruptor with estrgenic properties,which is a widely used industrial platicizer.When exposure to BPA for long-term,it would impact on multiple systems and organs including reproductive.developmental,neurological,endocrine function and so on,particularly in obesity.ExpoSUre to BPA during pregnancy and postnate,it can increase the sensitivity to obesity in offsprings.BPA may be contributed to obesity by enhancing triglyceride accumulation and accelerating adipocytes differentiation,affecting endocrine function of adipocytes and blood glucose and insulin metabolism.However,the dosage effect of BPA is not a simple linear rehionship.The impact of environment-related dosage on the human is worthy ot research in future.