Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults
Nutrition Research and Practice
; : 334-339, 2017.
Article
em En
| WPRIM
| ID: wpr-44069
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/OBJECTIVES: Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it is unclear whether the alcohol flush reaction, which is an alcohol-related trait predominantly due to acetaldehyde dehydrogenase deficiency, is associated with telomere length. This cross-sectional study aimed to evaluate the associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length (LTL). SUBJECTS/METHODS: The study included 1,803 Korean adults. Participants provided blood specimens for LTL measurement assay and reported their alcohol drinking status and the presence of an alcohol flush reaction via a questionnaire-based interview. Relative LTL was determined by using a quantitative polymerase chain reaction. Statistical analysis used multiple linear regression models stratified by sex and age groups, and potential confounding factors were considered. RESULTS: Age-specific analyses showed that heavy alcohol consumption (> 30 g/day) was strongly associated with a reduced LTL in participants aged ≥ 65 years (P 15 g/day of alcohol (P < 0.01). No significant alcohol consumption or alcohol flush reaction associations with LTL were observed in the sex-specific analyses. CONCLUSIONS: The results suggest that older alcohol drinkers, particularly those with the alcohol flush reaction, may have an accelerated aging process.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Oxirredutases
/
Envelhecimento
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Consumo de Bebidas Alcoólicas
/
Modelos Lineares
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Reação em Cadeia da Polimerase
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Estudos Transversais
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Telômero
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Aldeído Desidrogenase
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Leucócitos
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Acetaldeído
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Humans
Idioma:
En
Revista:
Nutrition Research and Practice
Ano de publicação:
2017
Tipo de documento:
Article