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Gegenqinlian decoction decreases serum TNF-αlevel in rats with chronic periodontitis and atherosclerosis / 实用口腔医学杂志
Article em Zh | WPRIM | ID: wpr-462078
Biblioteca responsável: WPRO
ABSTRACT
Objective:To investigate the effect of gegenqinlian on serum TNF-αlevel in rats with chronic periodontitis and athero-sclerotic.Methods:40 healthy male Wistar rats were randomly divided into control group(N,n =10)and model group(D,n =30).After model establishment and identfication the rats in model group were divided into D1,D2,D3,D4 and D5 groups(n =5) and were administered with saline,metronidazole,atorvastatin,metronidazole combined with atorvastatin and gegenqinlian respec-tively for 4 weeks.Periodontal indexes(PD and AL)were measured,the maximum intima-media thickness of abdominal aorta(IMT) was pathologically examined,TNF-αlevel was detected by ELISA.Results:After treatment PD,AL and serum TNF-αlevels in D2,D3,D4 and D5 groups were significantly lower than those in D1 group(P 0.05).Conclusion:Gegenqinlian can reduce serum level of TNF-αin rats,suggesting that the drug is effective in the treatment of periodontitis with atherosclerosis.
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Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Practical Stomatology Ano de publicação: 2015 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Practical Stomatology Ano de publicação: 2015 Tipo de documento: Article