Assessing Radiosensitivity of Lung Cancer with the Expression ofγH2AX / 天津医药
Tianjin Medical Journal
; (12): 867-869, 2014.
Article
em Zh
| WPRIM
| ID: wpr-474043
Biblioteca responsável:
WPRO
ABSTRACT
Objective To observe the relationship between expression changes of γH2AX and the radiosensitivity of lung cancer cells in vitro. Methods The radiosensitivity of lung cancer cell lines A549 and SBC-3 was measured by clone forming assay. The DSBs damage of lung cancer cell lines A549 and SBC-3 was determined by Western blot assay. Re-sults The clone forming rates of lung cancer cell lines A549 and SBC-3 were gradually decreased with the increased radia-tion dose.γH2AX expression was related to the cell radiosensitivity 1 hour and 6 hours after radiated. Conclusion The phosphorylated histoneγH2AX is a powerful tool to monitor DNA DSBs and to predict the radiosensitivity in lung cancer ra-diotherapy.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Tianjin Medical Journal
Ano de publicação:
2014
Tipo de documento:
Article