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Determination of Carfilzomib for Injection by HPLC / 中国药师
China Pharmacist ; (12): 1959-1960, 2016.
Article in Zh | WPRIM | ID: wpr-503315
Responsible library: WPRO
ABSTRACT
Objective:To establish an HPLC method to determine the content of carfilzomib for injection. Methods:The chroma-tographic column was a Waters symmetry C18(250 mm ×4.6 mm, 5 μm)column, the sample solvent was methanol, the mobile phase was 0. 05% trifluoroacetic acid-acetonitrile(57 ∶43) at a flow rate of 1. 0 ml · min-1 , the detection wavelength was 210 nm, the col-umn temperature was 25℃ and the injection volume was 10 ml. Results:The linear range of carfilzomib was 120-600 μg·ml-1 ( r=0. 999 7). The average recovery was 100. 4%( RSD=0. 24%,n=9). Conclusion:The method is rapid and effective, which can be used for the content determination of carfilzomib for injection.
Key words
Full text: 1 Database: WPRIM Language: Zh Journal: China Pharmacist Year: 2016 Document type: Article
Full text: 1 Database: WPRIM Language: Zh Journal: China Pharmacist Year: 2016 Document type: Article