Effects of anthocyanin on cholesterol efflux from mouse peritoneal macrophage foam cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-524924
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To explore the effect of anthocyanin on cholesterol efflux and elucidate its possible molecular mechanism.METHODS:
Mouse Peritoneal macrophages were loaded with 50 mg/L AcLDL to induce macrophage-derived foam cells. Cholesterol efflux from macrophage-derived foam cells induced by anthocyanin was determined by enzymatic methods. PPAR-? mRNA and protein expression in macrophage-derived foam cells was assayed by quantitative PCR and western blotting.RESULTS:
Anthocyanins had the capacity of promoting cholesterol efflux from mouse peritoneal macrophage-derived foam cells and increased PPAR-? mRNA and protein expression.CONCLUSION:
Anthocyain-induced cholesterol efflux may be related to its enhancing PPAR-? mRNA and protein expression.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
1989
Tipo de documento:
Artigo