The Effect of Piper Hancei Extract on the Atherosclerosis of Rabbits / 中国药房

ABSTRACT

OBJECTIVE:To observe the effect of Pipers hancei extract on the atherosclerosis of rabbits fed with high lipid food and to discuss its mechanism of action.METHODS:The rabbits were divided into high lipid group,Pipers hancei groups (high,medium and low dose groups),which were fed with high lipid food for 3 weeks before administered with medicine or normal saline,12 weeks later,the blood lipid,pathological changes of aortic plaque and lesion of coronary artery,serum superoxide dismutase (SOD)activity and serum malondialdehyde (MDA)activity were determined,in which a control group was established.RESULTS:Compared with the high lipid group,the levels of serum total cholesterol (TC),triglycerides (TG)and low density lipoprotein (LDL)have been significantly decreased for the high dose Pipers hancei group(P