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Effect of Manganese on Apoptosis,p53 and Bcl-2 Expression in Spermatogenic Cells of Rats / 环境与健康杂志
Article em Zh | WPRIM | ID: wpr-544834
Biblioteca responsável: WPRO
ABSTRACT
Objective To study the effect of manganese chloride on apoptosis,p53 and Bcl-2 expression in the spermatogenic cells of rats.Methods 24 healthy male SD rats were randomly divided into three groups.Two groups were treated with MnCl2?4H2O through intraperitoneal injection at 15 mg/kg and 30 mg/kg respectively,once a day and 5 times in a week for four weeks,the third group served as the control and given normal saline.The spermatogenic cell apoptosis was examined by transmission electronic microscope and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL)technique.Expression of p53 and Bcl-2 were measured with immunohistochemistry.Results The apoptosis index(AI)and p53-positive-cell rate in manganese exposed group were significantly higher than those in the control group(P
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Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Environment and Health Ano de publicação: 1992 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Environment and Health Ano de publicação: 1992 Tipo de documento: Article