Effects of implantation of the Cholinergic Antagonists into Four Different Brain Areas on Neurogenic Stress Response in Rats / 第二军医大学学报

ABSTRACT

The present study was undertaken to observe the effect of implantation of the anti-cholinergic agents into different brain areas hypothalamic paraventricular nucleus (PVH), ventral and dorsal hippocampus, thalamus; and to analyse their effect on the neurogenic stress response. The experiment was performed in 60 anesthetized rats with sciatic nerve stimulation. It was found that atropine and hexamethonium implantation into PVH markedly inhibited the adrenocortical response evoked by sciatic stimuli at 30 and 60 min following stimulation. Vehicle implant in the same region was ineffective, suggesting that the action of the agent was specific in the PVR The implantation of atropine into the ventral hippocampus was effective at 30 min following onset of stimulation, and atropine implant in the dorsal hippocampus was ineffective. The above data suggest that atropine and hexamethonium have effect of inhibiting plasma corticosterone level following sciatic stimulation by acting through cholinergic M and N receptors on PVH and nearby neural tissue and that cholinergic M receptors in the ventral hippocampus may be involved in the modulation of stress response.