EFFECTS OF SURAZEPAM ON THE CONTRACTILE FUNCTION OF UTERINE SMOOTH MUSCLE / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
em Zh
| WPRIM
| ID: wpr-550229
Biblioteca responsável:
WPRO
ABSTRACT
Surazepam ( Sur ) is a benzodiazepine derivative. Sur ( 0.2~0.27m-mol/L ) inhibited the contraction of isolated cervices uteri of rats and human beings induced by oxytocin and Ca2+ after high K+ concentration depolarization Sur ( 3.5~ 4 mg/kg ) iv could also inhibit the spontaneous contraction of uterus of rabbit in situ. The cumulative dose-response curves for Sur and CaCl2 exhibited non-competition.Both Sur and nifedipine markedly inhibited extracellular and intra-cellular Ca2+ dependent contraction induced by oxytocin.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Article