The effects of silymarin on the inhibition of nonenzymatic glycation and oxidation in aorta of streptozocin-induced diabetic rats / 第二军医大学学报
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-551527
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the inhibitory effects of silymarin on diabetic blood vessels chroniccomplication. Methods:
Silymarin was given to streptozocin-induced diabetic rats. Rats were killed 9 weeksafter treatment. Plasma LPO, fructosamine and RBC-SOD were measured. LPO, fruct0samine, fluores-cence intensities of AGEs, pentosidine and liperperoxide adducts in aorta were also measured.Results:
The early nonenzymatic glycation products-fructosamine were not inhibited, however, LPO and f1uores-cence intensities of AGEs, pentosidine,MDA and HNE adducts in aorta were more significantly reducedthan DM group.Conclusion:
The results suggest that silymarin may inhibit nonenzymatic glycation andoxidation in aorta of streptozocin-induced diabetic rats and control the diabetic chronic complication.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
1982
Tipo de documento:
Artigo