Effects of recombinant rat augmenter of liver regeneration on proliferation and secretion of transforming growth factor ft in glomerular mesangial cells / 中华肾脏病杂志
Chinese Journal of Nephrology
; (12)1997.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-552926
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the effect of recombinant rat augmenter of liver regeneration (rrALR) on the biological activities of rat glomerular mesangial cell(GMC) with or without IL-1?. Methods GMC proliferation and the level of TGF-? protein were determined by 3H-TdR incorporation and ELISA. Results The stimulating activity of IL-1? to rat GMC was enhanced by rrALR with the concentrations from 0.005 pg/ml to 0. 1ng/ml. But rrALR could not promote the proliferation of GMC without IL-1?. Conclusion rrALR may be a new mediator of inflammation, which promote proliferation and TGF-? secretion in rat GMC stimulated by IL-1?.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Nephrology
Ano de publicação:
1997
Tipo de documento:
Artigo